On the two-day oscillations and the day-to-day variability in global 3-D-modeling of the chemical system of the upper mesosphere/mesopause region

International audienceThe integration of the photochemical system of the upper mesosphere/mesopause region brought evidence that the system is able to respond in a nonlinear manner under certain conditions. Under the action of the diurnally-periodic insolation, the system creates subharmonic oscillations or chaos if disregarding strong diffusion, and under special conditions it possesses multiple solutions. The models used in the past were simplified and idealized in view of the number of dimensions and the consideration of the full dynamics. On the basis of our global 3-D-model of the dynamics and chemistry of the middle atmosphere (COMMA-IAP), we also found a nonlinear response in the photochemistry under realistic conditions. The model under consideration is not yet self-consistent, but the chemical model uses the dynamical fields calculated by the dynamic model. From our calculations we got period-2 oscillations of the photochemical system within confined latitudinal regions around the solstices but not during the equinoxes. The consequence of the period-2 oscillation of the chemical active minor constituents is that a marked two-day variation of the chemical heating rates is an important thermal pumping mechanism. We discuss these findings particularly in terms of the influence of realistic dynamics on the creation of nonlinear effects

Long-term behavior of the concentration of the minor constituents in the mesosphere – a model study

We investigate the influence the rising concentrations of methane, nitrous oxide and carbon dioxide which have occurred since the pre-industrial era, have had on the chemistry of the mesosphere. For this investigation we use our global 3-D-model COMMA-IAP which was designed for the exploration of the MLT-region and in particular the extended mesopause region. Assumptions and approximations for the trends in the Lyman-α flux (needed for the water vapor dissociation rate), methane and the water vapor mixing ratio at the hygropause are necessary to accomplish this study. To approximate the solar Lyman-α flux back to the pre-industrial time, we derived a quadratic fit using the sunspot number record which extends back to 1749 and is the only solar proxy available for the Lyman-α flux prior to 1947. We assume that methane increases with a constant growth rate from the pre-industrial era to the present. An unsolved problem for the model calculations consists of how the water vapor mixing ratio at the hygropause should be specified during this period. We assume that the hygropause was dryer during pre-industrial times than the present. As a consequence of methane oxidation, the model simulation indicates that the middle atmosphere has become more humid as a result of the rising methane concentration, but with some dependence on height and with a small time delay of few years. The solar influence on the water vapor mixing ratio is insignificant below about 80 km in summer high latitudes, but becomes increasingly more important above this altitude. The enhanced water vapor concentration increases the hydrogen radical concentration and reduces the mesospheric ozone. A second region of stronger ozone decrease is located in the vicinity of the stratopause. Increases in CO<sub>2</sub> concentration enhance slightly the concentration of CO in the mesosphere. However, its influence upon the chemistry is small and its main effect is connected with a cooling of the upper atmosphere. The long-term behavior of water vapor is discussed in particular with respect to its impact on the NLC region

Long-term trends of the concentration of the minor constituents in the mesosphere ? a model study

International audienceWe investigate the influence of the rising concentrations of methane, dinitrogen oxide and carbon dioxide since the pre-industrial era upon the chemistry of the mesosphere. We use for calculations our global 3D-model COMMA-IAP designed for the exploration of the MLT-region and particularly the extended mesopause region. In order to get approximated data of the solar Lyman-? flux back to the pre-industrial time, we derived a quadratic fit using the sunspot number available since 1749 as the only solar proxy for the Lyman-? flux before 1947. The Lyman-? flux values are employed to determine the water vapor dissociation rate. The water vapor trend analysis utilizes estimated methane trends since the pre-industrial era. An unsolved problem for the model calculations consists of the water vapor mixing ratio at the hygropause during the time range of trend calculation. We assume that the hygropause was dryer at the pre-industrial time than currently. As a consequence of the methane oxidation, the middle atmosphere became more humid according to the rising methane concentration, but depending on height and with a small time delay of few years. The solar influence on the water vapor mixing ratio is insignificant below about 80 km within summery high latitudes, but it becomes increasingly more important above this altitude. The growing water vapor concentration increases the hydrogen radical concentration and reduces the mesospheric ozone. A second region of stronger ozone decrease is located in the vicinity of the stratopause. Increasing CO2 concentration enhances slightly the concentration of CO in the mesosphere, but its influence upon the chemistry is small and its main effect is connected with a cooling of the upper atmosphere. We discuss the trends particularly in view of the impact on the NLC region

Retrieval of water vapor profile in the mesosphere from satellite ozone and hydroxyl measurements by the basic dynamic model of mesospheric photochemical system

We propose an indirect method for retrieving a number of significant minor gas constituents of the atmosphere. The technique is based on the use of so-called basic dynamic models of atmospheric photochemical systems simplified mathematically correctly in a special manner. It is applied to a mesospheric system describing day evolution of key minor gas constituents at these heights. We take as initial data experimental data of the CRISTA-MAHRSI satellite campaign of August 1997 during which ozone and hydroxyl (O<sub>3</sub> and OH) concentrations were measured simultaneously. It is demonstrated that the use of the basic dynamic model allows retrieval of vertical distribution (within the 53–85 km range of heights) of water vapor concentration that is one of the control parameters of the mesospheric photochemistry

Observation of radiative spin-polarization at 60.6 GeV

Radiative spin-polarization has been used extensively at LEP to accurately measure the beam energy around the Z resonance. As the LEP physics has moved on to the W boson the calibration based on polarization must be extended towards higher beam energies. This is difficult as the depolarizing effects of spin resonances grow rapidly with beam energy. At LEP it has been possible for the first time to measure transverse beam polarization at 60.6 GeV. To allow a build-up of polarization the tunes and the energy were chosen accurately. A low phase advance optics was used and careful orbit correction was carried out using dynamic beam based alignment data. Harmonic spin matching was applied both in a deterministic and a novel semi- empirical way. (11 refs)

Recent Results on Energy Calibration at LEP

The determination of the centre-of-mass energy at the four experiments installed on the CERN Large Electron Positron (LEP) collider is one of the major ingredients in the Standard Model investigations being carried on in the context of the experimental programme. Several depolarising effects at beam energies beyond 60 GeV limit the application of the Resonant Depolarisation (RD) method, which provi des an energy uncertainty of about ±1 MeV at the Z0 resonance. Extrapolation techniques from magnetic field measurements are used to obtain beam energies in the W-pair region, aiming at a total energy error £15 MeV. Consistency checks over a large range of precisely calibrated energies are mandatory to contain systematic errors from extrapolation. Progress obtained in extending the polarisable ener gy range in the 1997 LEP Run and the preliminary extrapolation errors are reported

Performance of the single and twin-aperture models of the 6 kA superconducting quadrupole for the LHC insertions

The LHC dispersion suppressors and matching sections will be equipped with individually powered superconducting quadrupoles with an aperture of 56 mm. In order to optimise the parameters and cost of the magnets and of their powering, the quadrupole has been designed on the basis of an 8.2 mm wide Rutherford-type cable for a nominal current of 5300 A, corresponding to a gradient of 200 T/m at 1.9 K. In order to validate the design two 1-m single-aperture quadrupoles and one twin-aperture quadrupole have been built and tested. In this report we describe the construction features of the magnets and present the results of the magnet tests. (4 refs)

Comparative evaluation of the treatment efficacy of suberoylanilide hydroxamic acid (SAHA) and paclitaxel in ovarian cancer cell lines and primary ovarian cancer cells from patients

BACKGROUND: In most patients with ovarian cancer, diagnosis occurs after the tumour has disseminated beyond the ovaries. In these cases, post-surgical taxane/platinum combination chemotherapy is the "gold standard". However, most of the patients experience disease relapse and eventually die due to the emergence of chemotherapy resistance. Histone deacetylase inhibitors are novel anticancer agents that hold promise to improve patient outcome. METHODS: We compared a prototypic histone deacetylase inhibitor, suberoylanilide hydroxamic acid (SAHA), and paclitaxel for their treatment efficacy in ovarian cancer cell lines and in primary patient-derived ovarian cancer cells. The primary cancer cells were isolated from malignant ascites collected from five patients with stage III ovarian carcinomas. Cytotoxic activities were evaluated by Alamar Blue assay and by caspase-3 activation. The ability of SAHA to kill drug-resistant 2780AD cells was also assessed. RESULTS: By employing the cell lines OVCAR-3, SK-OV-3, and A2780, we established SAHA at concentrations of 1 to 20 μM to be as efficient in inducing cell death as paclitaxel at concentrations of 3 to 300 nM. Consequently, we treated the patient-derived cancer cells with these doses of the drugs. All five isolates were sensitive to SAHA, with cell killing ranging from 21% to 63% after a 72-h exposure to 20 μM SAHA, while four of them were resistant to paclitaxel (i.e., <10% cell death at 300 nM paclitaxel for 72 hours). Likewise, treatment with SAHA led to an increase in caspase-3 activity in all five isolates, whereas treatment with paclitaxel had no effect on caspase-3 activity in three of them. 2780AD cells were responsive to SAHA but resistant to paclitaxel. CONCLUSION: These ex vivo findings raise the possibility that SAHA may prove effective in the treatment of paclitaxel-resistant ovarian cancer in vivo

Life Cycle Management of Infrastructures

By definition, life cycle management (LCM) is a framework “of concepts, techniques, and procedures to address environmental, economic, technological, and social aspects of products and organizations in order to achieve continuous ‘sustainable’ improvement from a life cycle perspective” (Hunkeler et al.\ua02001). Thus, LCM theoretically integrates all sustainability dimensions, and strives to provide a holistic perspective. It also assists in the efficient and effective use of constrained natural and financial resources to reduce negative impacts on society (Sonnemann and Leeuw\ua02006; Adibi et al.\ua02015). The LCM of infrastructures is the adaptation of product life cycle management (PLM) as techniques to the design, construction, and management of infrastructures. Infrastructure life cycle management requires accurate and extensive information that might be generated through different kinds of intelligent and connected information workflows, such as building information modeling (BIM)

Histone deacetylases as new therapy targets for platinum-resistant epithelial ovarian cancer

Introduction: In developed countries, ovarian cancer is the fourth most common cancer in women. Due to the nonspecific symptomatology associated with the disease many patients with ovarian cancer are diagnosed late, which leads to significantly poorer prognosis. Apart from surgery and radiotherapy, a substantial number of ovarian cancer patients will undergo chemotherapy and platinum based agents are the mainstream first-line therapy for this disease. Despite the initial efficacy of these therapies, many women relapse; therefore, strategies for second-line therapies are required. Regulation of DNA transcription is crucial for tumour progression, metastasis and chemoresistance which offers potential for novel drug targets. Methods: We have reviewed the existing literature on the role of histone deacetylases, nuclear enzymes regulating gene transcription. Results and conclusion: Analysis of available data suggests that a signifant proportion of drug resistance stems from abberant gene expression, therefore HDAC inhibitors are amongst the most promising therapeutic targets for cancer treatment. Together with genetic testing, they may have a potential to serve as base for patient-adapted therapies